PubMed hits on microdialysis

Microdialysis has been described in over 15745 scientific publications as of May 2015 (PubMed), mostly describing relative changes of endogenous compounds in the brain with the regular microdialysis technique. PubMed hits 1807 publications with keyword microdialysis & pharmacokinetics and 3325 for microdialysis & humans.


MetaQuant microdialysis probes

Beaumont V, Park L, Rassoulpour A, Dijkman U, Heikkinen T, Lehtimaki K, Kontkanen O, Al NR, Bates GP, Gleyzes M, Steidl E, Ramboz S, Murphy C, Beconi MG, Dominguez C, Munoz-Sanjuan I, 2014. The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease. PLoS. Curr. 6.

Cajina M, Nattini M, Song D, Smagin G, Jorgensen EB, Chandrasena G, Bundgaard C, Toft DB, Huang X, Acher F, Doller D, 2014. Qualification of LSP1-2111 as a Brain Penetrant Group III Metabotropic Glutamate Receptor Orthosteric Agonist. ACS Med. Chem. Lett. 5: 119-123.

Cremers T, Ebert B, 2007. Plasma and CNS concentrations of Gaboxadol in rats following subcutaneous administration. Eur. J. Pharmacol. 562: 47-52.

Cremers TI, de Vries MG, Huinink KD, Loon JP, Hart MV, Westerink BH, de Lange EC, 2008. Quantitative microdialysis using modified ultraslow microdialysis: Direct rapid and reliable determination of free brain concentrations with the MetaQuant technique. J. Neurosci. Methods.

Cremers TI, Flik G, Hofland C, Stratford RE, Jr., 2012. Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain. Drug Metab Dispos.

Danysz W, Flik G, McCreary A, Tober C, Dimpfel W, Bizot JC, Kostrzewa R, Brown RW, Jatzke CC, Greco S, Jenssen AK, Parsons CG, 2015. Effects of sarizotan in animal models of ADHD: challenging pharmacokinetic-pharmacodynamic relationships. J. Neural Transm. 122: 1221-1238.

Li CH, Stratford RE, Jr., Velez de MN, Cremers TI, Pollock BG, Mulsant BH, Remington G, Bies RR, 2014. Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokinetics. J. Transl. Med. 12: 203.

Nagel J, Greco S, Parsons CG, Flik G, Tober C, Klein KU, Danysz W, 2015. Brain concentrations of mGluR5 negative allosteric modulator MTEP in relation to receptor occupancy--Comparison to MPEP. Pharmacol. Rep. 67: 624-630.

Rollema H, Shrikhande A, Ward KM, Tingley FD, III, Coe JW, O'Neill BT, Tseng E, Wang EQ, Mather RJ, Hurst RS, Williams KE, de VM, Cremers T, Bertrand S, Bertrand D, 2010. Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. Br. J. Pharmacol. 160: 334-345.

Sane R, Wu SP, Zhang R, Gallo JM, 2014. The effect of ABCG2 and ABCC4 on the pharmacokinetics of methotrexate in the brain. Drug Metab Dispos. 42: 537-540.

Sood P, Cole S, Fraier D, Young AM, 2009. Evaluation of metaquant microdialysis for measurement of absolute concentrations of amphetamine and dopamine in brain: a viable method for assessing pharmacokinetic profile of drugs in the brain. J. Neurosci. Methods 185: 39-44.

Weber ML, Hofland CM, Shaffer CL, Flik G, Cremers T, Hurst RS, Rollema H, 2013. Therapeutic doses of antidepressants are projected not to inhibit human alpha4beta2 nicotinic acetylcholine receptors. Neuropharmacology 72: 88-95.

Normal microdialysis probes

Ackaert OW, De GJ, Capancioni R, la Pasqua OE, Dijkstra D, Westerink BH, Danhof M, Bouwstra JA, 2010. The in vitro and in vivo evaluation of new synthesized prodrugs of 5-OH-DPAT for iontophoretic delivery. J. Control Release 144: 296-305.

Allers KA, Dremencov E, Ceci A, Flik G, Ferger B, Cremers TI, Ittrich C, Sommer B, 2010. Acute and repeated flibanserin administration in female rats modulates monoamines differentially across brain areas: a microdialysis study. J. Sex Med. 7: 1757-1767.

Bloms-Funke P, Dremencov E, Cremers TI, Tzschentke TM, 2011. Tramadol increases extracellular levels of serotonin and noradrenaline as measured by in vivo microdialysis in the ventral hippocampus of freely-moving rats. Neurosci. Lett. 490: 191-195.

Bosker FJ, Cremers TI, Jongsma ME, Westerink BH, Wikstrom HV, den Boer JA, 2001. Acute and chronic effects of citalopram on postsynaptic 5-hydroxytryptamine(1A) receptor-mediated feedback: a microdialysis study in the amygdala. J. Neurochem. 76: 1645-1653.

Bosker FJ, Folgering JH, Gladkevich AV, Schmidt A, van der Hart MC, Sprouse J, den Boer JA, Westerink BH, Cremers TI, 2009. Antagonism of 5-HT(1A) receptors uncovers an excitatory effect of SSRIs on 5-HT neuronal activity, an action probably mediated by 5-HT(7) receptors. J. Neurochem. 108: 1126-1135.

Bosker FJ, Tanke MA, Jongsma ME, Cremers TI, Jagtman E, Pietersen CY, Van Der Hart MG, Gladkevich AV, Kema IP, Westerink BH, Korf J, den Boer JA, 2010. Biochemical and behavioral effects of long-term citalopram administration and discontinuation in rats: role of serotonin synthesis. Neurochem. Int. 57: 948-957.

Bubser M, de Brabander JM, Timmerman W, Feenstra MG, Erdtsieck-Ernste EB, Rinkens A, van Uum JF, Westerink BH, 1998. Disinhibition of the mediodorsal thalamus induces fos-like immunoreactivity in both pyramidal and GABA-containing neurons in the medial prefrontal cortex of rats, but does not affect prefrontal extracellular GABA levels. Synapse 30: 156-165.

Cremers TI, Dremencov E, Bosker FJ, Westerink BH, 2010. Oxazepam and temazepam attenuate paroxetine-induced elevation of serotonin levels in guinea-pig hippocampus. Int. J. Neuropsychopharmacol.: 1-5.

Cremers TI, Giorgetti M, Bosker FJ, Hogg S, Arnt J, Mork A, Honig G, Bogeso KP, Westerink BH, den BH, Wikstrom HV, Tecott LH, 2004. Inactivation of 5-HT(2C) receptors potentiates consequences of serotonin reuptake blockade. Neuropsychopharmacology 29: 1782-1789.

Cremers TI, Rea K, Bosker FJ, Wikstrom HV, Hogg S, Mork A, Westerink BH, 2007. Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic studies. Neuropsychopharmacology 32: 1550-1557.

Cremers TI, Teisman AC, van Gilst WH, Westerink BH, 1997. Use of microdialysis for monitoring sympathetic and parasympathetic innervation of heart in conscious rats. Am. J. Physiol 273: H2850-H2856.

Cremers TI, Wiersma LJ, Bosker FJ, den Boer JA, Westerink BH, Wikstrom HV, 2001. Is the beneficial antidepressant effect of coadministration of pindolol really due to somatodendritic autoreceptor antagonism? Biol. Psychiatry 50: 13-21.

de Leeuw van Weenen JE, Hu L, Jansen-van ZK, de Vries MG, Tamsma JT, Romijn JA, Pijl H, 2009. Four weeks high fat feeding induces insulin resistance without affecting dopamine release or gene expression patterns in the hypothalamus of C57Bl6 mice. Brain Res. 1250: 141-148.

Drijfhout WJ, De Vries JB, Homan EJ, Brons HF, Copinga S, Gruppen G, Beresford IJ, Hagan RM, Grol CJ, Westerink BH, 1999. Novel non-indolic melatonin receptor agonists differentially entrain endogenous melatonin rhythm and increase its amplitude. Eur. J. Pharmacol. 382: 157-166.

Fell MJ, Flik G, Dijkman U, Folgering JH, Perry KW, Johnson BJ, Westerink BH, Svensson KA, 2015. Glutamatergic regulation of brain histamine neurons: In vivo microdialysis and electrophysiology studies in the rat. Neuropharmacology 99: 1-8.

Flik G, Dremencov E, Cremers TI, Folgering JH, Westerink BH, 2011. The role of cortical and hypothalamic histamine-3 receptors in the modulation of central histamine neurotransmission: an in vivo electrophysiology and microdialysis study. Eur. J. Neurosci. 34: 1747-1755.

Flik G, Folgering JH, Cremers TI, Westerink BH, Dremencov E, 2015. Interaction Between Brain Histamine and Serotonin, Norepinephrine, and Dopamine Systems: In Vivo Microdialysis and Electrophysiology Study. J. Mol. Neurosci. 56: 320-328.

Fossa AA, Wisialowski TA, Cremers T, van der HM, Tseng E, Deng S, Rollema H, Wang EQ, 2012. Improved preclinical cardiovascular therapeutic indices with long-term inhibition of norepinephrine reuptake using reboxetine. Toxicol. Appl. Pharmacol.

Giorgetti M, Gibbons JA, Bernales S, Alfaro IE, Drieu La RC, Cremers T, Altar CA, Wronski R, Hutter-Paier B, Protter AA, 2010. Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism. J. Pharmacol. Exp. Ther. 333: 748-757.

Iderberg H, McCreary AC, Varney MA, Kleven MS, Koek W, Bardin L, Depoortere R, Cenci MA, Newman-Tancredi A, 2015. NLX-112, a novel 5-HT1A receptor agonist for the treatment of l-DOPA-induced dyskinesia: Behavioral and neurochemical profile in rat. Exp. Neurol. 271: 335-350.

Jongsma ME, Bosker FJ, Cremers TI, Westerink BH, den Boer JA, 2005. The effect of chronic selective serotonin reuptake inhibitor treatment on serotonin 1B receptor sensitivity and HPA axis activity. Prog. Neuropsychopharmacol. Biol. Psychiatry 29: 738-744.

Kawahara H, Kawahara Y, Westerink BH, 2000. The role of afferents to the locus coeruleus in the handling stress-induced increase in the release of noradrenaline in the medial prefrontal cortex: a dual-probe microdialysis study in the rat brain. Eur. J. Pharmacol. 387: 279-286.

Kawahara H, Kawahara Y, Westerink BH, 2001. The noradrenaline-dopamine interaction in the rat medial prefrontal cortex studied by multi-probe microdialysis. Eur. J. Pharmacol. 418: 177-186.

Kawahara Y, Kawahara H, Westerink BH, 1999. Comparison of effects of hypotension and handling stress on the release of noradrenaline and dopamine in the locus coeruleus and medial prefrontal cortex of the rat. Naunyn Schmiedebergs Arch. Pharmacol. 360: 42-49.

Kawahara Y, Kawahara H, Westerink BH, 2002. Hypotension-induced dopamine release in prefrontal cortex is mediated by local glutamatergic projections at the level of nerve terminals. J. Neurochem. 81: 285-291.

King MV, Kurian N, Qin S, Papadopoulou N, Westerink BH, Cremers TI, Epping-Jordan MP, Le PE, Ray DE, Fone KC, Kendall DA, Marsden CA, Sharp TV, 2014. Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition. Neuropsychopharmacology 39: 464-476.

Kiss JP, Vizi ES, Westerink BH, 1999. Effect of neostigmine on the hippocampal noradrenaline release: role of cholinergic receptors. Neuroreport 10: 81-86.

Kleijn J, Cremers TI, Hofland CM, Westerink BH, 2011. CB-1 receptors modulate the effect of the selective serotonin reuptake inhibitor, citalopram on extracellular serotonin levels in the rat prefrontal cortex. Neurosci. Res. 70: 334-337.

Kleijn J, Folgering JH, van der Hart MC, Rollema H, Cremers TI, Westerink BH, 2011. Direct effect of nicotine on mesolimbic dopamine release in rat nucleus accumbens shell. Neurosci. Lett. 493: 55-58.

Kleijn J, Wiskerke J, Cremers TI, Schoffelmeer AN, Westerink BH, Pattij T, 2012. Effects of amphetamine on dopamine release in the rat nucleus accumbens shell region depend on cannabinoid CB1 receptor activation. Neurochem. Int. 60: 791-798.

Martins I, de Vries MG, Teixeira-Pinto A, Fadel J, Wilson SP, Westerink BH, Tavares I, 2013. Noradrenaline increases pain facilitation from the brain during inflammatory pain. Neuropharmacology 71: 299-307.

Millan MJ, Dekeyne A, Gobert A, Mannoury la CC, Brocco M, Rivet JM, Di CB, Lejeune F, Cremers TI, Flik G, de Jong TR, Olivier B, de NG, 2010. S41744, a dual neurokinin (NK)1 receptor antagonist and serotonin (5-HT) reuptake inhibitor with potential antidepressant properties: a comparison to aprepitant (MK869) and paroxetine. Eur. Neuropsychopharmacol. 20: 599-621.

Millan MJ, Loiseau F, Dekeyne A, Gobert A, Flik G, Cremers TI, Rivet JM, Sicard D, Billiras R, Brocco M, 2008. S33138 (N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1] benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenyl-acetamide), a preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent: III. Actions in models of therapeutic activity and induction of side effects. J. Pharmacol. Exp. Ther. 324: 1212-1226.

Moon BU, de Vries MG, Cordeiro CA, Westerink BH, Verpoorte E, 2013. Microdialysis-coupled enzymatic microreactor for in vivo glucose monitoring in rats. Anal. Chem. 85: 10949-10955.

Moon BU, Koster S, Wientjes KJ, Kwapiszewski RM, Schoonen AJ, Westerink BH, Verpoorte E, 2010. An enzymatic microreactor based on chaotic micromixing for enhanced amperometric detection in a continuous glucose monitoring application. Anal. Chem. 82: 6756-6763.

Moor E, Schirm E, Jacso J, Westerink BH, 1998. Involvement of medial septal glutamate and GABAA receptors in behaviour-induced acetylcholine release in the hippocampus: a dual probe microdialysis study. Brain Res. 789: 1-8.

Mork A, Montezinho LP, Miller S, Trippodi-Murphy C, Plath N, Li Y, Gulinello M, Sanchez C, 2013. Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats. Pharmacol. Biochem. Behav. 105: 41-50.

Pehrson AL, Cremers T, Betry C, Van Der Hart MG, Jorgensen L, Madsen M, Haddjeri N, Ebert B, Sanchez C, 2012. Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters-A rat microdialysis and electrophysiology study. Eur. Neuropsychopharmacol.

Pudovkina OL, Cremers TI, Westerink BH, 2003. Regulation of the release of serotonin in the dorsal raphe nucleus by alpha1 and alpha2 adrenoceptors. Synapse 50: 77-82.

Pudovkina OL, Westerink BH, 2005. Functional role of alpha1-adrenoceptors in the locus coeruleus: a microdialysis study. Brain Res. 1061: 50-56.

Rea K, Cremers TI, Westerink BH, 2005. HPLC conditions are critical for the detection of GABA by microdialysis. J. Neurochem. 94: 672-679.

Rea K, Folgering J, Westerink BH, Cremers TI, 2009. alpha1-Adrenoceptors modulate citalopram-induced serotonin release. Neuropharmacology.

Redrobe JP, Jorgensen M, Christoffersen CT, Montezinho LP, Bastlund JF, Carnerup M, Bundgaard C, Lerdrup L, Plath N, 2014. In vitro and in vivo characterisation of Lu AF64280, a novel, brain penetrant phosphodiesterase (PDE) 2A inhibitor: potential relevance to cognitive deficits in schizophrenia. Psychopharmacology (Berl) 231: 3151-3167.

Rollema H, Wilson GG, Lee TC, Folgering JH, Flik G, 2011. Effect of co-administration of varenicline and antidepressants on extracellular monoamine concentrations in rat prefrontal cortex. Neurochem. Int. 58: 78-84.

Sommer S, Danysz W, Russ H, Valastro B, Flik G, Hauber W, 2014. The dopamine reuptake inhibitor MRZ-9547 increases progressive ratio responding in rats. Int. J. Neuropsychopharmacol. 17: 2045-2056.

Sotty F, Folgering JH, Brennum LT, Hogg S, Mork A, Hertel P, Cremers TI, 2009. Relevance of dorsal raphe nucleus firing in serotonin 5-HT(2C) receptor blockade-induced augmentation of SSRIs effects. Neuropharmacology 57: 18-24.

Timmerman W, Bouma M, De Vries JB, Davis M, Westerink BH, 2000. A microdialysis study on the mechanism of action of gabapentin. Eur. J. Pharmacol. 398: 53-57.

Timmerman W, Cisci G, Nap A, De Vries JB, Westerink BH, 1999. Effects of handling on extracellular levels of glutamate and other amino acids in various areas of the brain measured by microdialysis. Brain Res. 833: 150-160.

Timmerman W, Westerhof F, van der Wal TI, Westerink BH, 1998. Striatal dopamine-glutamate interactions reflected in substantia nigra reticulata firing. Neuroreport 9: 3829-3836.

Tzschentke TM, Folgering JH, Flik G, De VJ, 2012. Tapentadol increases levels of noradrenaline in the rat spinal cord as measured by in vivo microdialysis. Neurosci. Lett. 507: 151-155.

Visser AK, Kleijn J, van Faassen MH, Dremencov E, Flik G, Kema IP, den Boer JA, van WA, Dierckx RA, Bosker FJ, 2015. Serotonin-2C antagonism augments the effect of citalopram on serotonin and dopamine levels in the ventral tegmental area and nucleus accumbens. Neurochem. Int. 81: 10-15.

Weber ML, Hofland CM, Shaffer CL, Flik G, Cremers T, Hurst RS, Rollema H, 2013. Therapeutic doses of antidepressants are projected not to inhibit human alpha4beta2 nicotinic acetylcholine receptors. Neuropharmacology 72: 88-95.

Westerink BH, Cremers TI, De Vries JB, Liefers H, Tran N, De BP, 2002. Evidence for activation of histamine H3 autoreceptors during handling stress in the prefrontal cortex of the rat. Synapse 43: 238-243.

Westerink BH, De Vries JB, 2001. A method to evaluate the diffusion rate of drugs from a microdialysis probe through brain tissue. J. Neurosci. Methods 109: 53-58.

Yamada M, Kawahara Y, Kaneko F, Kishikawa Y, Sotogaku N, Poppinga WJ, Folgering JH, Dremencov E, Kawahara H, Nishi A, 2013. Upregulation of the dorsal raphe nucleus-prefrontal cortex serotonin system by chronic treatment with escitalopram in hyposerotonergic Wistar-Kyoto rats. Neuropharmacology 72: 169-178.