The jugular vein microdialysis probe give researchers the ability to determine the free fraction of a compound in blood. New chemical entities and/or CNS compounds are prone to high protein binding. Implanting the MetaQuant probe in the brain and in the jugular vein is a good tool to get more insight in the kinetic profile of a compound.
|Polyacrylonitrile membrane (PAN) cut-off||45 - 50 kDa|
|Regenerated Cellulose (RC) cut-off||18 kDa|
|Membrane length||3 & 4 mm|
|PAN outer diameter||320 µm|
|RC outer diameter||216 µm|
|3Fr silicon shaft length rat||800 mm|
|2Fr silicon shaft length mice||450 mm|
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